Science Friday Folgen

A study finds that Peto’s Paradox, which states that larger animals are no more likely to get cancer than smaller ones, may not hold up. Also, a nearly complete predator skull was found in the Egyptian desert. Its lineage indicates that it was a top carnivore of the age.What Does An Animal’s Size Have To Do With Its Cancer Risk?If you throw a huge party, there’s more of a chance of problems than if you host a quiet get-together for a couple of friends. The logic is simple: Having more people around means more opportunities for chaos. Similarly, it would seem to make sense that in animals, a bigger species with more cells might have a greater chance of something going wrong with one of those cells, including mutations leading to cancer.Back in 1977, a British epidemiologist named Richard Peto observed that that didn’t seem to be true. Bigger animals didn’t seem to have a greater risk of cancer than smaller ones. That became known as Peto’s Paradox, and has been a topic of debate among cancer biologists ever since.Research published this week in the Proceedings of the National Academy of Sciences takes a new look at Peto’s Paradox using an unusual set of data—death reports from zoos around the world. Dr. Sarah Amend of Johns Hopkins Medical School joins Host Flora Lichtman to explain why, in their findings, Peto’s Paradox doesn’t seem to hold up—and what studying animal cancer rates could teach scientists about improving human health.Meet Bastetodon, A 30 Million-Year-Old Apex PredatorOnce upon a time, some 30 million years ago, what is now Egypt’s Western Desert was a lush forest. Humans had not evolved yet, the nearest relatives being monkey-like creatures. And through those forests stalked Bastetodon syrtos, a newly described apex predator from an extinct lineage known as the Hyaenodonts—one of the top carnivores of the age.Researchers recently discovered a nearly complete skull of the creature. They reported on the find in the Journal of Vertebrate Paleontology. Host Flora Lichtman talks with Shorouq Al-Ashqar of the Mansoura University Vertebrate Paleontology Center about the discovery, and the picture it helps paint of ancient life.Transcripts for each segment will be available after the show airs on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Changes limiting programs, grants, and even the nature of studies are already underway at the NIH, NSF, FDA, CDC, and more.On President Trump’s first day in office, he signed an executive order to end what he calls “illegal and immoral discrimination programs,” referencing diversity, equity, and inclusion (DEI) in the federal government. The repercussions of this are already being felt across science agencies.Things are changing fast: Last week, a federal judge in Maryland temporarily blocked parts of the DEI purge from being carried out. At the same time, federal research agencies have already made changes. For example, the National Institutes of Health suddenly pulled a program that provides grants to PhD students from marginalized backgrounds, and has already canceled studies mid-project, like one on LGBTQ cancer patients. The National Science Foundation has begun reviewing active research science projects that may not comply with Trump’s executive orders. The Centers for Disease Control and Prevention took down resources for HIV prevention, LGBTQ+ health, contraception, and more—then partially restored them, as ordered by a judge. And the Food and Drug Administration pulled its guidance on the importance of having some diversity in clinical trials, like those to test drugs and medical devices.So, what does banning diversity, equity, and inclusion efforts mean for medical research? And what does it mean for our health?Host Flora Lichtman talks with Dr. Rachel Hardeman, director of the Center for Antiracism Research for Health Equity at the University of Minnesota in Minneapolis; and Dr. Melissa Simon, an ob-gyn at Northwestern Medicine, and director of the Center for Health Equity Transformation in Chicago.Transcripts for each segment will be available after the show airs on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

The acting head of the NIH reportedly pushed back against legal guidance to resume grant funding, leaving federal workers in the lurch. Also, though fungi make up a tiny part of the human microbiome, they play an important role in both the prevention and development of many diseases.Cuts And Conflicting Directives Sow Confusion For NIH WorkersJust over a month after President Trump’s inauguration, federal science in the US is in a state of disarray. Executive orders to halt grant funding at the National Institutes of Health (NIH) have faced court challenges. Last week, a federal judge extended a restraining order on a proposal to cap NIH grant funding for indirect costs, costs that experts say are critical to their work. But according to new reporting, staff within the NIH have been left without clear guidance about moving forward with those grants, with the NIH’s acting director reportedly pushing back against legal guidance from the agency’s lawyers to restart distribution of the funding.Host Flora Lichtman is joined by Katherine J. Wu, staff writer for The Atlantic, who reported on the turmoil at the NIH. They also talk about other science news of the week, including an update on the measles outbreak in Texas, how to see every planet in the solar system this week, and how scientists think runner Faith Kipeygon could be the first woman to break a four-minute mile.You’ve Heard Of The Microbiome—Welcome To The MycobiomeYou’ve heard of the microbiome, the community of bacteria, viruses, archaea parasites, and fungi that live in our bodies. But that last member of the group, fungi, get a lot less attention than the others. And perhaps that’s unsurprising. After all, bacteria outnumber fungi 999 to 1 in our guts.But now, scientists are beginning to piece together just how important fungi truly are. Disruption in the fungal balance can play a role in the development of Crohn’s disease, irritable bowel disease, celiac disease, colorectal cancer, some skin diseases, and more.Host Flora Lichtman talks with Dr. Mahmoud Ghannoum, microbiologist and professor at Case Western Reserve University’s School of Medicine, who has dedicated his career to studying the fungi in our bodies, and coined the term mycobiome over a decade ago.Transcripts for each segment will be available after the show airs on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.