The Science Behind The Psychedelics Boom
There’s been an explosion of new research into therapeutic uses for psychedelics. This includes drugs like psilocybin, the hallucinogenic chemical found in “magic mushrooms,” and ketamine—which was originally used as an anesthetic, and later became a popular party drug also known as “special K.”
Esketamine, a form of ketamine, was approved by the FDA in 2019 for use in treatment resistant depression. And just last month Colorado residents voted to legalize medicinal use of psilocybin. Following on the heels of Oregon’s legalization in 2020, which is now in the process of being implemented.
A recent study published in the New England Journal of Medicine showed promising results in using psilocybin to help patients with treatment-resistant depression. About a third of those who received the highest dose were in remission 3 weeks later. This was the largest look at psilocybin’s effect on depression to date, involving 233 participants across ten countries in Europe.
Ira talks with Dr. Steve Levine, senior vice president of patient access and medical affairs at COMPASS Pathways, the company that funded the study.
Later, Ira takes a closer look into the latest psychedelic research and takes listener calls with Dr. Gerard Sanacora, professor of psychiatry and director of the Yale Depression Research Program at the Yale School of Medicine, and Dr. Alissa Bazinet, Clinical Psychologist, Co-Founder and Director of Research and Development at the Sequoia Center, and Associate Director of the Social Neuroscience and Psychotherapy Lab at Oregon Health and Science University.
How Will AI Image Generators Affect Artists?
Back in August, controversy erupted around the winning submission of the Colorado State Fair’s art content. The winning painting wasn’t made by a human, but by an artificial intelligence app called Midjourney, which takes text prompts and turns them into striking imagery, with the help of a neural network and an enormous database of images.
AI-based text-to-image generators have been around for years, but their outputs were rudimentary and rough. The State Fair work showed this technology had taken a giant leap forward in its sophistication. Realistic, near-instant image generation was suddenly here—and reactions were just as potent as their creations.
Tech enthusiasts lauded the achievement, while artists were largely concerned and critical. If anyone could make a painting in just a few seconds, why would someone need to commission an artist to produce an illustration, or even bother spending years learning art at all?
Read the rest on sciencefriday.com.
Transcripts for each segment will be available the week after the show airs on sciencefriday.com.
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Covering the outer reaches of space to the tiniest microbes in our bodies, Science Friday is the source for entertaining and educational stories about science, technology, and other cool stuff.
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Folge vom 09.12.2022Medicinal Psychedelics Study, AI Art. December 9, 2022, Part 2
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Folge vom 09.12.2022The Future Of Birds In North America, 190th Birthday For Tortoise. December 9, 2022, Part 1Wish A Happy 190th Birthday To Jonathan The Tortoise A birthday should always be celebrated. For Jonathan the tortoise, who turned 190 this week, that celebration involved a salad cake and a three-day party. Jonathan is the oldest known living animal, hatched in 1832. Jonathan, who calls the island of St. Helena home, may be blind and unable to smell, but he maintains a good quality of life and even continues to mate with his companions. Jonathan’s ripe old age surpasses the typical tortoise life expectancy of 150 years. In other “old” news, scientists have found fragments of DNA one million years older than the previous record: making these samples two million years old. The fragments were found in Ice Age sediment in Northern Greenland, and are from a time where the climate was much warmer than it is now. Vox staff writer Umair Irfan joins Ira to talk about these and other science stories of the week, including an end to the monoclonal antibodies we have for COVID and the FDA’s first approval of fecal transplant therapy. The Joy And Sadness Of Bird Counting The state of the birds is not looking good. That’s the conclusion from a new report that looks at decades of community-collected population data from surveys like the annual Christmas Bird Count and the Breeding Bird Survey. Species that inhabit grasslands seem to fare the worst, with their populations down over 30 percent in the last 50 years. Meanwhile, dozens of newly identified “tipping point” species have lost 50 percent of their populations in the same time, and are poised to lose the same proportion in the coming half century. Dr. Amanda Rodewald of Cornell University’s Lab of Ornithology helps unpack the report’s key findings, including the good news: Decades of cooperative efforts to protect waterfowl have paid off in thriving duck populations. Rodewald explains what this can tell us about reversing declines in other habitats. Plus, birder and science writer Ryan Mandelbaum joins Ira and listeners to talk about the joys of winter birding, the upcoming Christmas Bird Count, and the feathery sightings that brighten our lives. Transcripts for each segment will be available the week after the show airs on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.
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Folge vom 02.12.2022Hawai'i's Volcanic Eruption, Science Of Chemistry Nobel, What Is ‘Swing’ In Jazz? Dec 2, 2022, Part 1Hawai’i’s Mauna Loa Volcanic Eruption Sparing Homes For Now Hawai’i’s famed Mauna Loa volcano began to erupt this past weekend, after weeks of increasing small earthquakes. So far the flow of lava is posing no risk to homes in nearby Hilo, though that could change rapidly. But in the meantime, an important climate research lab is without power and unable to make measurements. And as lava flows and cools into new rock formations, one unusual product, called Pele’s Hair, looks uniquely soft and straw-like—while being dangerously sharp. Ira talks to FiveThirtyEight’s Maggie Koerth about the less high profile side effects of a major volcanic eruption. Plus, a new analysis of the magma under Yellowstone National Park, the leadership potential for wolves infected with a cat parasite, and other research stories. A Nobel Prize For Chemistry Work ‘Totally Separate From Biology’ This year, the Nobel Prize in Chemistry went to Carolyn Bertozzi of Stanford University, Morten Meldal of the University of Copenhagen, and K. Barry Sharpless of the Scripps Research Institute “for the development of click chemistry and bioorthogonal chemistry.” In “click chemistry,” molecular building blocks snap together quickly and efficiently to let chemists build more complicated molecules. But bioorthogonal chemistry takes that work one step farther, allowing the technique to be used within living organisms without damaging cells. “When someone is thinking outside the box, or in a very different way, we like to think of that as orthogonal thinking,” Dr. Bertozzi explained. “So biorthogonal means not interacting with biology. Totally separate from biology.” Her research began with an interest in developing ways to see specific sugar molecules on the surface of cells. But it has developed into an approach that can be used for advanced drug delivery in fields such as chemotherapy. Bertozzi joins Ira Flatow for a wide-ranging conversation about her research, chemistry education, her early music career, and the importance of diversity in the field of chemistry. Scientists Discover What Makes Jazz Music Swing Swing is a propulsive, groovy feeling that makes you want to move with the music. It’s hard to put into words, but if you listen to jazz, you’ve probably felt it yourself. Now, researchers have arrived at a better understanding of what generates that feeling: Their work, published in Communications Physics, focuses on timing differences between a group’s soloist and its rhythm section. Joining Ira to discuss the new findings are Theo Geisel, a professor of theoretical physics at the University of Göttingen and the Max Planck Institute for Dynamics and Self Organization, and Javier Arau, a saxophonist and the founder and executive director of the New York Jazz Academy. Transcripts for each segment will be available the week after the show airs on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.
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Folge vom 02.12.2022Xenotransplantation, Internet of Things, Sea Life Essays, Water Taste-Testing. Dec 2, 2022, Part 2Consider Empathy For The Yeti Crab (And Other Sea Creatures, Too) It’s easy to empathize with certain animals: soft fur, big eyes, and family units make it simple to relate to creatures like panda bears, cats, and dogs. Even some undersea critters like dolphins and whales have large fan bases among land-dwelling humans. But the ocean is filled with many more creatures than just mammals, and many of them fall in the category of “weird.” Defector staff writer Sabrina Imbler thinks a lot about these critters that evade our categorization of “cute.” Things like deep sea worms, jelly-like invertebrates called salps, and the ghostly, hairy yeti crab are Imbler’s bread and butter. Imbler’s new book, How Far the Light Reaches: A Life in Ten Sea Creatures, is filled with essays comparing aspects of their life to bizarre creatures of the deep sea. From exploring their queer identity through the underwater dance parties of the yeti crab, to grappling with living as a mixed-race person through hybridized fish, each essay is poetic and intimate. SciFri producer Kathleen Davis chats with Imbler from their home in Brooklyn, New York, about the importance of finding empathy with the strangest creatures on our planet. Read an excerpt from How Far the Light Reaches: A Life in Ten Sea Creatures here. Advances In Pig-To-Human Organ Transplantation Hold Promise Earlier this year a pig heart was successfully transplanted into a human for the very first time. Unfortunately, the patient lived for just under 2 months. But it still marks a big milestone in the field of xenotransplantation, or transplanting organs from one species to another. Scientists are optimistic that advances in pig-to-human organ transplantation could save the lives of some of the over 100,000 people in the waiting for organ donations in the United States. Ira talks with Dr. Muhammad Mohiuddin, professor of surgery and director of the Cardiac Xenotransplantation Program at the University of Maryland School of Medicine, about what he’s learned in the 10 months since the historic heart transplant, and about the barriers to widespread acceptance of interspecies organ transplantation. Later, Ira talks with Dr. Megan Sykes, professor and director of the Center for Translational Immunology at Columbia University about how scientists decided that pigs were suitable organ donors in the first place, and the latest advancements in pig-to-human organ transplantation research. Teaching Your Smart Devices To Get Along If you’ve ever tried to connect a new Internet of Things device in your home, such as a smart plug or light, you know it can be a complicated process. Not every device works with every other device, and even the most tech-savvy customer may find themself turning to Reddit for help troubleshooting. These are problems a new Internet of Things standard called Matter aims to solve. Created by a coalition of home device companies, Matter allows devices that run it to speak to each other, set up seamlessly, and communicate securely. The standard officially launched in early November with dozens of new Matter-enabled devices. Ira talks to Jennifer Pattison Tuohy of The Verge about the problems Matter aims to solve, and some of the practical hitches along the road to a more seamless smart home. Putting Tap Water To The Test Every time you turn on the tap, you become the last stop in a complicated journey. Water from snow and streams collects in lakes and reservoirs, and cities pump it through complex filtration systems to make it pure enough to drink. The particular balance of invisible minerals in each pour from your kitchen tap makes for subtle differences in every glass. One might call it the terroir of tap water. In a bustling hotel ballroom, surrounded by exhibition booths showing off the latest pipes, pumps and filters, a panel of judges gathered to spot those differences. I was one of them. The American Water Works Association assembled a panel of water wonks for its Rocky Mountain regional meeting in the ski resort town of Keystone. Here, we put tap water to the test, blind tasting samples from six cities across Colorado to crown a winner. To read the rest of the article, visit sciencefriday.com. Transcripts for each segment will be available the week after the show airs on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.