Science Friday Folgen

Last month the FDA approved a new treatment for sickle cell disease, the first medical therapy to use CRISPR gene editing technology. It works by identifying the gene or genes causing the disorder, modifying those genes and then returning them to the patient’s body.There are now two gene therapies offered by pharmaceutical companies for sickle cell disease: Casgevy from Vertex Pharmaceuticals and CRISPR Therapeutics, and Lyfgenia from BlueBird Bio. But prices for these one-time treatments are steep: Casgevy costs $2.2 million per patient and Lyfgenia $3.1 million.Both promise a full cure, which would be life-changing for patients with this debilitating condition. Over 100,000 Americans, mostly of African descent, have sickle cell disease.This milestone raises more questions: What will be the next disease that CRISPR can help cure? And is it possible to reduce the costs of gene therapy treatments?Ira talks with Dr. Fyodor Urnov, professor of molecular and cell biology and scientific director of technology and translation at the Innovative Genomics Institute, based at the University of California, Berkeley, about the future of CRISPR-based cures.Transcripts for this segment will be available the week after the show airs on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

A team of scientists in Ecuador is on a mission to describe new-to-science tarantula species to help secure conservation protections. And, undergraduate researchers pasted striped capes onto termites’ backs to see if a well-known warning sign would fend off predators.Protecting The ‘Satan’ Tarantula and Other Lovable Giant SpidersA team of scientists in Ecuador is on a mission to find and describe species of an understudied, often unpopular group of critters: mygalomorphs, a group of large, stocky spiders that includes tarantulas. In late 2023, two of these researchers published a paper in the journal ZooKeys describing two new-to-science tarantula species, including one named Psalmopoeus satanas—affectionately called the “Satan tarantula” because of its erratic behavior.Tarantulas are understudied in Ecuador, and there are many species left to describe. They’re also threatened by mining, agriculture, and the illegal pet trade. That’s what led Pedro Peñaherrera-R., a researcher at Universidad San Francisco de Quito to found the Mygalomorphae Research Group. Its members are working to describe these spiders and secure conservation protections before they possibly disappear.Producer Rasha Aridi talks with Peñaherrera-R. and his co-author and fellow group member Roberto José León about how the Satan tarantula earned its name, how they discover and classify spiders, and why we should all show spiders a little more love.If Termites Wore Stripes, Would Spiders Still Eat Them?The animal kingdom is filled with colors and patterns. Sometimes, those colors are to signal to members of an animal’s own species, in a mating display for instance. In other cases, a bright color or vibrant pattern serves as a warning to potential predators—a signal saying “don’t eat me, I’m toxic.” That type of warning coloration, known as aposematism, can be seen in the bright colors of a poison dart frog, or the black, white, and yellow stripes of a monarch butterfly caterpillar.Bigger animals, like birds, are known to consider that sort of warning signal when hunting. Researchers at the University of Florida were interested in whether jumping spiders might also take that sort of striped warning coloration into account when choosing their prey. To find out, they applied tiny striped capes to the backs of laboratory termites to study whether those stripes affected the behavior of hungry jumping spiders. They found that while the test spiders did notice the striped termites more than termites wearing solid colors, the spiders were less likely to attack striped termites when given the chance to do so.Behavioral ecologist Dr. Lisa Taylor joins Ira to discuss the purpose of the project—and former lead undergraduate researcher Lauren Gawel describes the challenges of trying to get termites to dress up as superheroes.Transcripts for each segment will be available after the show airs on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Cancer, at its core, is a genetic disease: the result of DNA mutations that cause cells to grow out of control and develop tumors. And over the years, scientists have identified certain chemicals, called carcinogens, that are directly linked to those cancer-causing mutations, like those found in cigarettes.But the rates of some cancers, like colorectal and lung, are rising dramatically in certain populations, leaving scientists to wonder what carcinogens they might be missing, and how traditional models of detecting them are falling short.Last year, a landmark study published in the journal Nature confirmed a theory that toxicologists and cancer researchers had long suspected: that certain chemicals, like those found in air pollution, may not directly lead to cancerous mutations, but instead prime already vulnerable mutated cells to become cancerous. Some scientists have dubbed these chemicals “dark matter” carcinogens; they know they’re out there, exerting some kind of effect on increasing cancer rates, but they don’t fully understand what these chemicals are.Dr. Siddhartha Mukherjee, Pulitzer Prize-winning author and assistant professor of medicine at Columbia University, wrote about this scientific detective mystery in The New Yorker. This week, he joins Ira to talk about how scientists are rethinking their approach to identifying carcinogens, and why he’s hopeful for the future of cancer research in light of this new paradigm.Transcripts for this segment will be available the week after the show airs on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.